Spatio-temporal maps of the wall displacement were used to analyze the regional pulse wave propagations and velocities. In this study, simulations are performed in inhomogeneous aortic walls with hard inclusions of different numbers, size and modulus in order to further characterize the effects of focal hardening on pulse wave propagation. A two-way-coupled fluid-structure interaction (FSI) simulation study of pulse wave propagation along inhomogeneous aortas with focal stiffening and softening has previously proved the model reliable. Such methods may not prove effective in detecting focal wall changes as entailed by a range of cardiovascular diseases. Conventional clinical methods involve a global examination of the pulse traveling between femoral and carotid arteries, to provide an average PWV estimate. stiffer the wall, higher the PWV), and can potentially enhance the noninvasive diagnostic techniques. Pulse Wave velocity ( PWV) and propagation along the aortic wall have been shown to depend on the wall stiffness ( i.e. Changes in aortic wall material properties, such as stiffness, have been shown to accompany onset and progression of various cardiovascular pathologies.
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